Bioassay-Guided Isolation of Antiproliferative Compounds from Grape (Vitis vinifera) Stems

Bioassay - guided Isolation of Antiproliferative Triterpenoids

The Evolutionary Genomics of Grape (Vitis vinifera ssp. vinifera) Domestication

Evolutionary genomics of grape (Vitis vinifera ssp. vinifera) domestication

We gathered genomic data from grapes (Vitis vinifera ssp. vinifera), a clonally propagated perennial crop, to address three ongoing mysteries about plant domestication. The first is the duration of domestication; archaeological evidence suggests that domestication occurs over millennia, but genetic evidence indicates that it can occur rapidly. We estimated that our wild and cultivated grape sam...

Bioassay-guided isolation and identification of antifungal compounds from ginger.

A bioassay-guided isolation of antifungal compounds from an African land race of ginger, Zingiber officinale Roscoe, led to the identification of [6], [8] and [10]-gingerols and [6]-gingerdiol as the main antifungal principles. The compounds were active against 13 human pathogens at concentrations of <1 mg/mL. The gingerol content of the African land race was at least 3 x higher than that of ty...

Bioactivity-guided isolation of antiproliferative compounds from Centaurea carduiformis DC

In this study, antiproliferative activity of methanol extract of Centaura carduiformis DC. subsp. carduiformis var. carduiformis DC (CC) was examined against Vero, HeLa and C6 cell lines in 1000 and 500 mg/mL concentrations using the BrdU ELISA assay. The CC root (CCR) has the most effective antiproliferative activity. The root extract was fractionated using various solvent and determined antip...